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Posts Tagged ‘FDA’

FDA Establishes Guidelines For Drug Disposal

Sunday, October 18th, 2009

Recently, the FDA published guidelines that outline the most appropriate way to dispose of medications. These medications may be out of date or be medications that may not be prescribed anymore, but may be left over supply stored in medicine cabinets or closets in homes.

In asking the general public about drug disposal, most respond that the most appropriate way to dispose of medications is by flushing them down the toliet; however, it is important to note that disposal by flushing is not recommended for the vast majority of medicines.

Unused or expired medicines that do not have flushing directions in the label can be disposed of safely in the household trash by:
1. Mixing them with something that will hide the medicine or make it unappealing, such as
     kitty litter or used coffee grounds.
2. Placing the mixture in a container such as a sealed plastic bag.
3. Throwing the container in your household trash.

The medicines on the list below that are recommended for disposal by flushing are safe and effective when used as prescribed, but they could be especially harmful to a child, pet, or anyone else if taken accidentally. Some of the possible harmful effects include breathing difficulties or heart problems, possibly leading to death. For these reasons, FDA advises that flushing these medicines down the sink or toilet is currently the best way to immediately and permanently remove the risk of harm from the home.

Medications Recommended for Disposal by FLUSHING:

Medicine, Active Ingredient
Actiq, oral transmucosal lozenge, Fentanyl Citrate
Avinza, capsules (extended release), Morphine Sulfate
Daytrana, transdermal patch system, Methylphenidate
Demerol, tablets, Meperidine Hydrochloride
Demerol, oral solution, Meperidine Hydrochloride
Diastat/Diastat AcuDial, rectal gel, Diazepam
Dilaudid, tablets, Hydromorphone Hydrochloride
Dilaudid, oral liquid, Hydromorphone Hydrochloride
Dolophine Hydrochloride, tablets, Methadone Hydrochloride
Duragesic, patch (extended release), Fentanyl
Embeda, capsules (extended release), Morphine Sulfate; Naltrexone Hydrochloride
Fentora, tablets (buccal), Fentanyl Citrate
Kadian, capsules (extended release), Morphine Sulfate
Methadone Hydrochloride, oral solution *, Methadone Hydrochloride
Methadose, tablets, Methadone Hydrochloride
Morphine Sulfate, tablets (immediate release), Morphine Sulfate
Morphine Sulfate, oral solution, Morphine Sulfate
MS Contin, tablets (extended release), Morphine Sulfate
Onsolis, soluble film (buccal), Fentanyl Citrate
Opana, tablets (immediate release), Oxymorphone Hydrochloride
Opana ER, tablets (extended release), Oxymorphone Hydrochloride
Oramorph SR, tablets (sustained release), Morphine Sulfate
Oxycontin, tablets (extended release), Oxycodone Hydrochloride
Percocet, tablets, Acetaminophen; Oxycodone Hydrochloride
Percodan, tablets, Aspirin; Oxycodone Hydrochloride
Xyrem, oral solution, Sodium Oxybate

As you can see, the majority of the medications listed above are narcotic pain medications used to treat patients with chronic pain conditions. Many times those who suffer with chronic pain must try a number of different medications before finding the one that is effective for them. This can result in a supply of unused medications stored in the home that pose a danger to children and pets.

With Daylight Savings time ending, it is a good time to check your medicine cabinet, or wherever you store your medications, and dispose of ones that are out of date or any unused medications that you are no longer prescribed. Be sure to follow the disposal guidelines above- if you have any questions, visit the FDA website at www.fda.gov or ask your pharmacist.

John M. Williamson, PharmD

New Tylenol Recommendations Could Affect Chronic Pain Patients

Wednesday, July 8th, 2009

New dosing recommendations for Tylenol (acetaminophen), the most commonly prescribed drug in the United States, could change how we deal with issues from headaches to chronic pain. An FDA advisory panel of 37 physicians and pharmacists made recommendations to lower the maximum daily dose of acetaminophen in over-the-counter drugs to 2600mg from the current level of 4000mg, and urged the FDA to make extra-strength doses (two 500-milligram pills) of the drug available only by prescription. They also urged the FDA to reduce the maximum single dose to 650 milligrams from 1000 milligrams.

If you suffer from chronic pain, the FDA may consider reformulating prescription medications such as Vicodin and Percocet, both of which contain varying amounts of acetaminophen in combination with an opioid. Americans filled nearly 125 million prescriptions for these medications last year alone.

So what’s all the fuss about Tylenol anyway?

It is important to realize that acetaminophen, when taken properly, is a very safe and effective medication. In excess, however, it is harmful. Acetaminophen toxicity kills about 100 people a year, sends over 56,000 to the emergency room annually, and is the number one cause of liver transplants. Most all of these cases are the result of accidental overdoses, because in most products, acetaminophen is not the primary ingredient. As a result, we ingest more acetaminophen than intended.

What do we do in the meantime?

While we wait for the FDA to make final decisions about these new recommendations, let’s use this as an opportunity to take a closer look at the acetaminophen content in any medications that we take. Add it up. Am I taking a total amount of more than 4000mg of acetaminophen in a 24 hour period? Be sure to include both prescription and over-the-counter medications. If you need some help or have questions about the content of your medications, talk with your pharmacist. Remember- your pharmacist is your medication expert.

John M. Williamson, PharmD



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